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Table 4 Top ranked 10 genes with highest values of either degree or betweenness. Network analysis in Cytoscape was carried out on GCN. Moderated t-test was performed for examining differential expression of these genes between NSCLC cases and controls (E-GEOD-19188). Pearson’s correlation coefficients were calculated between ALDOA and these genes

From: Elevated transcriptional levels of aldolase A (ALDOA) associates with cell cycle-related genes in patients with NSCLC and several solid tumors

Gene ID Symbole r a P a valueb logFCc P a valued
991 CDC20 0.399 0.003 3.234 1.49E-33
9833 MELK 0.358 0.008 2.866 3.14E-32
9232 PTTG1 0.356 0.009 1.989 7.06E-26
9133 CCNB2 0.350 0.010 2.935 3.63E-33
8318 CDC45 0.414 0.002 1.933 3.09E-27
79023 NUP37 0.401 0.003 0.894 7.08E-20
891 CCNB1 0.395 0.004 2.734 1.14E-32
7083 TK1 0.503 <0.001 1.746 4.55E-26
5690 PSMB2 0.456 0.001 0.748 1.39E-19
29089 UBE2T 0.363 0.007 2.868 2.27E-38
55143 CDCA8 0.351 0.010 1.817 8.39E-32
55165 CEP55 0.372 0.006 2.754 5.51E-30
  1. a r was the Pearson’s correlation coefficient of this gene with ALDOA; b P a value was calculated by the Pearson’s correlation method adjusted by Benjamini & Hochberg method.; clogFC represented log base 2 of FC, which was the expression level ratio between cancer and control; d P a value was calculated by the Moderated t-statistic method adjusted by Benjamini & Hochberg method. eThe bond symbols represented top ranked genes with highest values of degree, while the italic symbols indicated top ranked genes with highest values of betweenness
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BioData Mining

ISSN: 1756-0381