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Table 5 Partial correlation analyses for reassessing the relationship of ALDOA and hub genes. Partial correlation analyses were performed in R-package ‘corpcor’ to reassess the relationship between ALDOA and hub genes (the top ranked 10 genes with highest values of either degree or betweenness)

From: Elevated transcriptional levels of aldolase A (ALDOA) associates with cell cycle-related genes in patients with NSCLC and several solid tumors

  Symbol HK2 PKM
r p a P b r p c P d
GSE19188 TK1 0.408 6.45E-05 0.424 3.14E-05
CDC45 0.302 3.82E-03 0.356 5.78E-04
CCNB1 0.290 5.51E-03 0.364 4.19E-04
CDC20 0.284 6.77E-03 0.336 1.19E-03
NUP37 0.275 8.74E-03 0.370 3.28E-04
UBE2T 0.264 1.20E-02 0.326 1.73E-03
CDCA8 0.254 1.60E-02 0.278 7.87E-03
CEP55 0.236 2.50E-02 0.310 2.93E-03
CCNB2 0.230 2.90E-02 0.323 1.87E-03
MELK 0.220 3.70E-02 0.299 4.18E-03
PSMB2 0.206 5.20E-02 0.163 1.25E-01
PTTG1 0.193 6.90E-02 0.369 3.40E-04
TCGA-LUAD TK1 0.442 <2.2E-16 0.296 7.44E-12
PSMB2 0.438 <2.2E-16 0.334 7.99E-15
UBE2T 0.384 <2.2E-16 0.318 1.44E-13
CDC20 0.369 <2.2E-16 0.271 4.34E-10
CCNB1 0.367 <2.2E-16 0.242 2.76E-08
PTTG1 0.347 4.44E-16 0.289 2.39E-11
NUP37 0.346 6.66E-16 0.190 1.44E-05
CCNB2 0.312 4.59E-13 0.150 6.60E-04
CDC45 0.297 6.85E-12 0.184 2.77E-05
CDCA8 0.287 3.08E-11 0.189 1.60E-05
CEP55 0.263 1.40E-09 0.143 1.18E-03
MELK 0.242 2.80E-08 0.157 3.64E-04
  1. a r p was the correlation coefficient between ALDOA and the other genes using partial correlation analyses with P values (b P) when controlling HK2 expression at the transcriptional level; Likewise, c r p was the partial correlation coefficient between ALDOA and the other genes with P values (d P) when controlling PKM expression at the transcriptional level