Elevated transcriptional levels of aldolase A (ALDOA) associates with cell cycle-related genes in patients with NSCLC and several solid tumors

Table 6 3-year and 5-year OS rates of patients with different expression level of AA genes with or without ALDOA expression. Z-test was used to compare OS rates between different groups

AA genes^a	Sample size	3-year OS			5-year OS
AA genes^a	Sample size	OS rate	Z ^b	P	OS rate	Z ^b	P
CDC20 L	98	0.582	0.156	0.876	0.439	0.582	0.561
CDC20 H	98	0.571			0.398
CDC20 H ALDOA H	55	0.491	1.515	0.130	0.309	1.938	0.053
others	141	0.61			0.461
MELK L	98	0.52	1.601	0.109	0.367	1.447	0.148
MELK H	98	0.633			0.469
MELK H ALDOA H	54	0.426	2.947	0.003	0.259	3.122	0.002
others	142	0.634			0.479
PTTG1 L	98	0.592	0.439	0.661	0.480	1.745	0.081
PTTG1 H	98	0.561			0.357
PTTG1 H ALDOA H	53	0.491	1.472	0.141	0.245	3.000	0.003
others	143	0.608			0.483
CDC45 L	98	0.633	1.601	0.109	0.490	2.029	0.042
CDC45 H	98	0.52			0.347
CDC45 H ALDOA H	58	0.466	2.031	0.042	0.276	2.617	0.009
others	138	0.623			0.478
CCNB1 L	98	0.643	1.884	0.060	0.510	2.597	0.009
CCNB1 H	98	0.51			0.327
CCNB1 H ALDOA H	54	0.463	1.987	0.047	0.259	2.790	0.005
others	142	0.62			0.479
TK1 L	98	0.612	1.005	0.314	0.480	1.745	0.081
TK1 H	98	0.541			0.357
TK1 H ALDOA H	59	0.475	1.885	0.059	0.288	2.421	0.015
others	137	0.62			0.439

^aPatients in the cohort E-GEOD-37745 were divided into one group of patients with low expression of hub gene and the other group of patients with high expression of hub gene, or divided into one group of patients with high expression of both hub gene and ALDOA, and the other group of patients with other expression levels; ^bThe difference of 3-year and 5-year OS rates between the group of patients with low and high expression of hub gene, or between the group of patients with high expression of both AA and ALDOA, and the other group of patients with other expression levels were compared by Z-test respectively

ISSN: 1756-0381